An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

LINN, Stuart M.

1 entries
  • 12028

Host specificity of DNA produced by Escherichia coli, X. In vitro restriction of phage FD replicative form.

Proc. Nat. Acad. Sci. (USA), 59, 1300-1306, 1968.

Order of authorship in the original publication: Linn, Arber. Arber announced the discovery, with proof, of the first restriction endonuclease (restriction enzyme or restrictase)."These enzymes are found in bacteria and archaea and provide a defence mechanism against invading viruses.[4][5] Inside a prokaryote, the restriction enzymes selectively cut up foreign DNA in a process called restriction digestion; meanwhile, host DNA is protected by a modification enzyme (a methyltransferase) that modifies the prokaryotic DNA and blocks cleavage. Together, these two processes form the restriction modification system.[6]"

Digital facsimile from PubMedCentral at this link.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Restriction Enzyme or Restriction Endonuclease, IMMUNOLOGY