An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

LEE, Rosalind C.

1 entries
  • 14010

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.

Cell, 75, 843-854, 1993.

Ambros and colleagues discovered the first known microRNA (miRNA), a small single-stranded non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression. The human genome may encode over 1900 miRNAs, although more recent analysis suggests that the number is closer to 2,300.

The first human disease associated with deregulation of miRNAs was chronic lymphocytic leukemia. In this disorder, the miRNAs work as both tumor suppressors and oncogenes.

Order of authorship in the original publication: Lee, Feinbaum, Ambros.



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis