An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

MILLER, J.

1 entries
  • 13936

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

EMBO Journal, 4, 1609-1614, 1985.

Discovery of Zinc fingers, a protein structural motif. "Zinc fingers were first identified in a study of transcription in the African clawed frogXenopus laevis in the laboratory of Aaron Klug. A study of the transcription of a particular RNA sequence revealed that the binding strength of a small transcription factor (transcription factor IIIA; TFIIIA) was due to the presence of zinc-coordinating finger-like structures.[6] Amino acid sequencing of TFIIIA revealed nine tandem sequences of 30 amino acids, including two invariant pairs of cysteine and histidine residues. Extended x-ray absorption fine structure confirmed the identity of the zinc ligands: two cysteines and two histidines.[5] The DNA-binding loop formed by the coordination of these ligands by zinc were thought to resemble fingers, hence the name" (Wikipedia article on Zinc finger, accessed 7-22).



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Structure