An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

HUNTER, Antony Rex "Tony"

1 entries
  • 13985

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.

Proc. Nat. Acad. Sci. (USA), 77, 1311-1315, 1980.

Tony Hunter discovered that tyrosine phosphorylation is a fundamental mechanism for transmembrane-signal transduction in response to growth factor stimulation, and that disregulation of such tyrosine phosphorylation, by activated oncogenic protein tyrosine kinases, is a pivotal mechanism utilized in the malignant transformation of cells. This cell-signaling mechanism revolutionized basic research on cancer. Digital facsimile from PubMedCentral at this link.



Subjects: ONCOLOGY & CANCER