Wood of Edinburgh was the first (1853) to employ hypodermic injection that used a true syringe and hollow needle as a therapeutic procedure. He referred to his invention as "subcutaneous" rather than hypodermic. See also Brit. med. J., 1858, 721-23, for a later paper by him. A full account of his work is given by Howard-Jones (No. 2063). Digital facsimile from ncbi.nlm.nih.gov at this link.