An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

GURDON, Sir John Bertrand

2 entries
  • 256.12

Adult frogs derived from the nuclei of single somatic cells.

Developmental Biology 4, 256-73, 1962.

Demonstration that somatic and germinal nuclei are genetically equivalent. Using somatic cell nuclear transfer (SCNT),  Gurdon (Nobel Prize 2012) transplanted cell nuclei from mature intestinal tadpole cells into enucleated eggs, which developed into normal tadpoles. This contradicted the textbook dogma that adult cells are irrevocably assigned to their specific functions and cannot assume new ones. The egg was able to reprogram the introduced nucleus and direct its genes to switch from the duties of an intestinal cell to those appropriate to a developing egg.




Subjects: BIOLOGY › Cell Biology, BIOLOGY › Developmental Biology, GENETICS / HEREDITY, Regenerative Medicine
  • 14064

"Fertile" intestine nuclei.

Nature, 210, 1240-1241, 1966.

Gurdon (Nobel Prize 2012) and Uehlinger replaced the cell nucleus of frog ova with frog intestinal nuclei to generate tadpoles, some of which became fertile adult male and female frogs.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › Cell Biology, BIOLOGY › Developmental Biology, Regenerative Medicine