An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

McCULLOCH, Ernest Armstrong

2 entries
  • 12427

Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells.

Nature, 197, 452-4, 1963.

McCulloch and Till discovered the blood-forming stem cell, the hematopoietic stem cell (HSC), through their pioneering work in mice. McCulloch and Till began a series of experiments in which bone marrow cells were injected into irradiated mice. They observed lumps in the spleens of the mice that were linearly proportional to the number of bone marrow cells injected. They hypothesized that each lump (colony) was a clone arising from a single marrow cell (stem cell). With Andrew Becker they demonstrated that each nodule arose from a single cell.



Subjects: BIOLOGY › Cell Biology, Regenerative Medicine
  • 12428

The distribution of colony-forming cells among spleen colonies.

Journal of Cell and Comparative Physiology, 62, 327-336, 1963.

Evidence that stem cells are capable of self-renewal. (Order of authorship in the original publication: Siminovitch, McCullch, Till). Digital facsimile from tspace.library.utoronto.ca at this link.



Subjects: BIOLOGY › Cell Biology, Regenerative Medicine